Our proteogenomics working group aims to federating researchers in genomics, proteomics, bioinformatics and biostatistics from different laboratories to foster and initiate multi-omics research projects in biomedical science.
Despite the fact that genomics and proteomics are highly complementary research domains, there has only recently been emergence of international biomedical research projects integrating both technologies. The US National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) combined large-scale genome and proteome analyses to better understand the molecular bases of cancer. “Launched in 2011, CPTAC pioneered the integrated proteogenomic analysis of colorectal, breast and ovarian cancer to reveal new insights into these cancer types, such as identification of proteomic-centric subtypes, prioritization of driver mutations by correlative analysis of copy number alterations and protein abundance, and understanding cancer-relevant pathways through post-translational modifications.“
Founding members of our proteogenomics working group come from the National Human Genome Research Center (CNRGH) and from the Proteomics lab (EDyP) within the Biosciences and Biotechnology research Institute (BIG). First projects that could benefit from synergy between genomic and proteomic technologies have been recently initiated. Researchers interested in this initative are welcome to contact us.
Proteogenomics working group 